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Sialoglycoprotein and carbohydrate complexes in chromium toxicity
Rachel Codd1, Jennifer A Irwin, Peter A Lay
1Centre for Heavy Metals Research, School of Chemistry, University of Sydney, NSW 2006, Australia.
Current Opinion in Chemical Biology
|April 26, 2003
Summary
Chromium(VI) compounds are industrial carcinogens. Research shows oxoCr(V) complexes with sialoglycoproteins and carbohydrates may play roles in chromium metabolism and genotoxicity.
Area of Science:
- Environmental Science
- Toxicology
- Biochemistry
Background:
- Chromium(VI) compounds are significant industrial carcinogens.
- Environmental exposure to chromium(VI) is a growing concern.
- Sialoglycoproteins and carbohydrates are involved in stabilizing chromium intermediates.
Purpose of the Study:
- To characterize oxoCr(V)-sialoglycoprotein and -carbohydrate complexes.
- To investigate the role of these complexes in chromium(VI) metabolism.
- To explore their potential involvement in chromium(VI)-induced genotoxicity.
Main Methods:
- Molecular characterization of oxoCr(V) complexes.
- Analysis of extracellular and intracellular reduction of chromium(VI).
- Investigating the interaction of chromium species with biological molecules.
Main Results:
- OxoCr(V) complexes with sialoglycoproteins and carbohydrates were characterized.
- These complexes are formed during chromium(VI) reduction.
- Potential roles in chromium metabolism and genotoxicity were identified.
Conclusions:
- OxoCr(V) complexes are key intermediates in chromium(VI) toxicity.
- Extracellular sialoglycoproteins and intracellular D-glucose complexes are significant.
- Further research is needed to fully understand their role in carcinogenesis.