Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evolution of function in (beta/alpha)8-barrel enzymes.

John A Gerlt1, Frank M Raushel

  • 1Department of Biochemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA. j-gertl@uiuc.edu

Current Opinion in Chemical Biology
|April 26, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Elucidation of the Pathway for the Biosynthesis of the Undecorated Capsular Polysaccharide from the HS:19 Serotype of the Human Pathogen <i>Campylobacter jejuni</i>.

Biochemistry·2026
Same author

Metabolic thermodynamics: pertinent reference state and energy potentials.

The FEBS journal·2026
Same author

Light-Triggered Accelerated Degradation of Surface-Bound Chemical Agents.

Journal of the American Chemical Society·2026
Same author

Enzymatic Synthesis of an Undecorated Capsular Polysaccharide from <i>Campylobacter jejuni</i>.

Biochemistry·2025
Same author

Biosynthesis of CDP-α-d-fucofuranose and CDP-β-l-6-deoxy-altrofuranose for the Capsular Polysaccharides of <i>Campylobacter jejuni</i>.

Biochemistry·2025
Same author

The use of phosphotriesterase in the synthesis of enantiomerically pure ProTide prodrugs.

Chemico-biological interactions·2025
Same journal

Function through shape: An overview of DNA G-quadruplexes in transcriptional regulation.

Current opinion in chemical biology·2026
Same journal

Advances in tools and technologies for multiplexed bioluminescence imaging.

Current opinion in chemical biology·2026
Same journal

High-resolution molecular mapping by expansion-coupled label-free and multimodal imaging.

Current opinion in chemical biology·2026
Same journal

Recent advances in glycoconjugate-based therapeutics.

Current opinion in chemical biology·2026
Same journal

Towards better red emitters for bioimaging: Innovations in rhodamine and cyanine chemistry.

Current opinion in chemical biology·2026
Same journal

Chemigenetic fluorescent biosensors in biological imaging - New trends and advances.

Current opinion in chemical biology·2026
See all related articles

The common beta/alpha-barrel fold is found in many enzymes. Researchers are investigating if these enzymes evolved from a common ancestor or through convergent evolution, using studies of natural, designed, and directed evolution.

Area of Science:

  • Biochemistry
  • Enzymology
  • Structural Biology

Background:

  • The beta/alpha-barrel is the most prevalent structural fold among characterized enzymes.
  • The evolutionary origins of functionally diverse enzymes sharing this fold remain unclear.

Purpose of the Study:

  • To explore the evolutionary pathways of beta/alpha-barrel enzymes.
  • To investigate whether functional diversity arose from divergent or convergent evolution.

Main Methods:

  • Analysis of natural enzyme superfamilies.
  • Examination of designed enzymes with novel functions.
  • Studies involving directed evolution to alter enzyme function.

Main Results:

  • Recent research has focused on understanding the evolution of function within beta/alpha-barrel enzyme superfamilies.

Related Experiment Videos

  • Investigated natural, designed, and directed evolution approaches.

    • Conclusions:

    • The expansion of sequence databases is expected to provide further insights into the evolutionary history of beta/alpha-barrel enzymes.
    • Understanding the evolution of these enzymes is crucial for enzyme engineering and synthetic biology.