[Noninvasive methods of diagnosis of diabetes mellitus]

The content of glucose was assessed in perspiration, which was induced by an introduction of medical preparations (during 5-10 min) into patient's skin by iontophoresis; the choice of the method was to avoid the risk of infection and pain. A high specific chromogenic substrate was used to determine the content of glucose in the perspiration, which improved the sensitivity of the method and made it possible to determine the quantitative content of glucose in just 5 minutes; or alternatively, the half-quantitative content of glucose could be determined, by using the specially designed high-sensitivity strips, in just 1 minute. The correlation between a concentration of perspiration glucose and a degree of glycemia makes it possible to assess the concentration of glucose in blood by avoiding the invasive diagnostics.