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Related Experiment Videos

[Respiratory effects of risperidone? A prospective study].

F Touraine1, M-T Antonini, D Bourlot

  • 1Service de Pathologie Respiratoire, Hôpital du Cluzeau, 51, avenue D.-Larrey, 87042 Limoges Cedex. bonnaud@unilim.fr

Revue De Pneumologie Clinique
|April 30, 2003
PubMed
Summary
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Risperidone, an atypical neuroleptic, may cause respiratory issues like cough and bronchial hyperreactivity. Further research is needed to understand these potential side effects in patients.

Area of Science:

  • Pharmacology
  • Pulmonology
  • Psychiatry

Context:

  • Risperidone is an atypical antipsychotic medication.
  • Respiratory symptoms have been anecdotally linked to risperidone use.
  • Patients with no prior respiratory conditions were the focus.

Purpose:

  • To prospectively evaluate the respiratory status of patients treated with risperidone over three months.
  • To identify potential respiratory side effects of risperidone.
  • To investigate the incidence of bronchial hyperreactivity.

Summary:

  • Thirty-nine patients were enrolled; 20 dropped out.
  • One patient experienced cough, likely risperidone-related, without functional change.
  • Two patients developed bronchial hyperreactivity, asymptomatic and without clinical signs.

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  • Bronchial hyperreactivity was noted in patients at inclusion, suggesting a potential baseline susceptibility.

    • Impact:

    • Risperidone may have secondary respiratory effects, including bronchial hyperreactivity.
    • The co-prescription of other psychiatric drugs, such as selective serotonin reuptake inhibitors, may potentiate these effects.
    • This study highlights the need for monitoring respiratory health in patients taking risperidone, especially in combination therapy.