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Related Experiment Videos

A new technic for obtaining blood from mice.

V J Lewis, W L Thacker, S H Mitchell

    Laboratory Animal Science
    |April 1, 1976
    PubMed
    Summary

    A new method efficiently collects serial blood samples from mice using a tail incision after heat exposure. This rapid, reliable technique yields sufficient samples for testing without significant hemolysis.

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    Area of Science:

    • Animal research methodology
    • Physiological sample collection

    Background:

    • Serial blood collection in mice is crucial for longitudinal studies.
    • Existing methods can be invasive, time-consuming, or require specialized skills.

    Purpose of the Study:

    • To describe a practical and humane technique for serial blood sample collection from mice.
    • To establish a reliable method for obtaining sufficient blood volumes for various analyses.

    Main Methods:

    • Blood collection via tail incision in mice.
    • Exposure of mice to elevated ambient temperature (45°C) prior to sampling.
    • Standardized collection procedure to minimize stress and hemolysis.

    Main Results:

    • The technique successfully yielded serial blood samples from mice.
    • Sufficient sample volumes for most laboratory tests were obtained.
    • Minimal to no significant hemolysis was observed in collected samples.

    Conclusions:

    • The described tail incision method is a practical, rapid, and reliable approach for serial blood collection in mice.
    • This humane technique requires no specialized skills, making it widely applicable.
    • The method facilitates longitudinal studies in mice by enabling repeated, high-quality blood sampling.

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