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[Acute renal failure probably associated with topiramate]
R Ferriols Lisart1, A Heras Javierre, M Sanz Muñoz
1Servicio de Farmacia. Hospital General de Castellón. Spain. ferriols_raf@gva.es
Summary
Topiramate use can cause acute kidney injury, characterized by rising creatinine and urea levels. Discontinuing the medication led to recovery, suggesting a causal link.
Area of Science:
- Nephrology
- Clinical Pharmacology
Background:
- Topiramate is an anticonvulsant and migraine prophylactic medication.
- Acute kidney injury (AKI) is a potential adverse effect of various medications.
Observation:
- A patient developed non-oliguric acute renal failure 5 days after initiating topiramate.
- Clinical presentation included elevated creatinine and serum urea, with decreased creatinine clearance.
Findings:
- Renal function parameters normalized after topiramate discontinuation.
- Renal ultrasonography and biopsy showed no significant pathological changes.
- The temporal association and exclusion of other causes strongly implicated topiramate.
Implications:
- Clinicians should consider topiramate as a potential cause of acute kidney injury.
- Monitoring renal function in patients on topiramate therapy is advisable.
- This case highlights the importance of medication review in unexplained renal dysfunction.