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Protective Effects of Tomato Juice on Mouse Skin Carcinogenesis

Sarmishtha De1, Sukta Das

  • 1Dept. of Cancer Chemoprevention, Chittaranjan National Cancer Institute, Calcutta- 7000 26, India sukta2001@rediffmail.com

Asian Pacific Journal of Cancer Prevention : APJCP
|April 30, 2003
PubMed

Insights

Tomato juice consumption may prevent skin cancer by boosting antioxidant enzymes and reducing harmful lipid peroxides. This study in mice suggests tomato

Area of Science:

  • Oncology
  • Nutritional Science
  • Biochemistry

Background:

  • Tomato juice is rich in antioxidants and chemopreventive agents.
  • Skin carcinogenesis is a complex process influenced by carcinogen exposure and host factors.

Purpose of the Study:

  • To investigate the anticarcinogenic effects of tomato juice in a mouse skin carcinogenesis model.
  • To explore the underlying mechanisms of tomato juice's protective action.

Main Methods:

  • Mice were administered tomato juice orally.
  • Skin carcinogenesis was induced using a carcinogen.
  • Levels of lipid peroxides and activity of liver detoxification enzymes (glutathione-S-transferase, glutathione peroxidase, superoxide dismutase) were measured.

Main Results:

  • Oral tomato juice administration protected against skin tumor development and increased lifespan.
  • Tomato juice intake decreased lipid peroxide levels.
  • Tomato juice significantly activated key liver detoxification enzymes suppressed by carcinogen exposure.

Conclusions:

  • Tomato juice exhibits a preventive role in carcinogenesis.
  • The protective effects are likely mediated by modulating host biotransformation and detoxification systems.
  • Antioxidant and chemopreventive compounds in tomato juice contribute to its anticarcinogenic properties.

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