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Cognitive dysfunction following adjuvant chemotherapy for breast cancer: two case studies
Karen Paraska1, Catherine M Bender
1School of Nursing, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. kparaska@libcom.com
Oncology Nursing Forum
|April 30, 2003
Summary
Chemotherapy for breast cancer can cause cognitive dysfunction, affecting memory and attention in 17%-50% of women. Reproductive changes and depression may contribute to these cognitive changes.
Area of Science:
- Oncology
- Neuroscience
- Psychology
Background:
- Adjuvant chemotherapy for breast cancer is a standard treatment.
- Cognitive dysfunction is a reported side effect impacting quality of life.
Observation:
- Two cases illustrate cognitive dysfunction post-chemotherapy.
- Symptoms include deficits in memory, attention, and psychomotor skills.
Findings:
- 17%-50% of breast cancer patients experience cognitive dysfunction after chemotherapy.
- Chemotherapy-induced reproductive status changes may underlie cognitive deficits.
- Depression can exacerbate or mimic cognitive dysfunction.
Implications:
- Understanding the interplay of cognitive dysfunction, reproductive hormones, and depression is crucial for developing interventions.
- Nurses play a key role in educating patients and families about potential cognitive changes and management strategies.