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Related Experiment Videos

Multinucleation in cleavage stage embryos.

Eric Van Royen1, Kathelijne Mangelschots, Miet Vercruyssen

  • 1Centre for Reproductive Medicine, Department of Obstetrics-Gynaecology-Fertility, Middelheim Hospital, Lindendreef 1, 2020 Antwerp, Belgium. eric.van.royen@pandora.be

Human Reproduction (Oxford, England)
|May 2, 2003
PubMed
Summary

Multinucleation, a common finding in embryo development, is linked to poorer implantation rates. This embryo characteristic should be considered during IVF assessments to improve success.

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Area of Science:

  • Embryology
  • Reproductive Medicine
  • In Vitro Fertilization (IVF)

Background:

  • Multinucleation is a morphological characteristic observed in human embryos during in vitro fertilization (IVF).
  • Understanding its incidence and correlation with clinical and morphological variables is crucial for improving IVF outcomes.

Purpose of the Study:

  • To analyze the incidence of multinucleation in cleavage stage embryos over time and across populations.
  • To investigate the correlation between multinucleation and clinical variables, embryo morphology, and implantation rates.

Main Methods:

  • Retrospective analysis of 10,388 cleavage stage embryos from 1,395 IVF/ICSI cycles.
  • Data collected from 700 patients between January 1, 1999, and June 30, 2002.

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Main Results:

  • Multinucleation was observed in 33.6% of embryos across 79.4% of cycles.
  • Incidence was higher on day 2 (27.4%) than day 3 (15.1%) and increased with fragmentation.
  • Multinucleated embryos showed a decreased implantation rate (4.3% single, 5.7% double transfers).

Conclusions:

  • Multinucleation is a frequent phenomenon in IVF.
  • It is associated with impaired embryo cleavage, increased fragmentation, and reduced implantation rates.
  • Multinucleation should be incorporated into routine embryo assessment protocols.