Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Interictal basal brain SPECT versus interictal activated brain SPECT in temporal cryptogenic epilepsy].

M A Gudin1, B Catalán Bernardos, V Poblete García

  • 1Neurología, Hospital Ntra. Sra. de Alarcos, Ciudad Real, Spain. mariagudin@arrakis.es

Neurologia (Barcelona, Spain)
|May 2, 2003
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Yield of xenodiagnosis and PCR in the evaluation of specific chemotherapy of Chagas' disease in children].

Boletin chileno de parasitologia·1998
Same author

[Percutaneous suprapubic bladder lithotripsy].

Annales d'urologie·1998
Same author

Factors associated with outcome in major depression: a 6-month prospective study.

Social psychiatry and psychiatric epidemiology·1998
Same author

[Simultaneous transplantation of fetal mesencephalic cells to the striatum and globus pallidus of rats with lesions induced by 6-hydroxydopamine].

Revista de neurologia·1998
Same author

Signs of glaucoma in rhesus monkeys from a restricted gene pool.

Journal of glaucoma·1998
Same author

The Bcl-2 gene is differentially regulated by IL-2 and IL-4: role of the transcription factor NF-AT.

Oncogene·1998

Interictal epileptiform activity in temporal epilepsy patients is linked to reduced brain perfusion in the temporal lobe, thalamus, and cerebellum. This suggests interictal epileptiform activity may represent a post-ictal state.

Area of Science:

  • Neurology
  • Neuroscience
  • Medical Imaging

Background:

  • Interictal epileptiform activity (IEA) is common in temporal epilepsy but its nature remains unclear.
  • IEA may represent microseizures or brain inhibition mechanisms.
  • Understanding brain metabolism during IEA is crucial for temporal epilepsy management.

Purpose of the Study:

  • To investigate brain perfusion during basal and interictal states in temporal epilepsy patients.
  • To quantify temporal, thalamic, and cerebellar perfusion using SPECT HMPAO.
  • To elucidate the metabolic underpinnings of IEA in temporal epilepsy.

Main Methods:

  • SPECT HMPAO imaging was performed on 24 temporal epilepsy patients (9 male/15 female, mean age 36.5 years).
  • Two studies were conducted: a basal state (no ictal activity) and an activated state (during IEA with ≥10 graphoelements/EEG page).

Related Experiment Videos

  • Digital analysis quantified perfusion in temporal, thalamic, and cerebellar regions.

    • Main Results:

    • A significant decrease in thalamic, temporal, and cerebellar perfusion was observed during the activated state compared to the basal state (p < 0.001).
    • A strong statistical relationship (R2 > 0.9) was found between perfusion in these three regions in both states.
    • These findings highlight a consistent pattern of reduced perfusion associated with IEA.

    Conclusions:

    • Temporal epilepsy is associated with significantly decreased thalamic, temporal, and cerebellar perfusion during interictal activity.
    • The observed perfusion changes suggest that IEA might reflect a post-ictal state.
    • Further research into IEA's metabolic correlates can inform epilepsy treatment strategies.