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Updated: Sep 26, 2026

Development of an Insert Co-culture System of Two Cellular Types in the Absence of Cell-Cell Contact
Published on: July 17, 2016
[Acute-phase reaction]
Bernard Bonnotte1, Nils-Olivier Olsson, Bernard Lorcerie
1INSERM U. 517 faculté de médecine de Dijon, service de médecine interne, immunologie clinique. Bernard.Bonnotte@u-bourgogne.fr
Abstract:
The systemic changes induced by inflammation have been referred as the acute-phase response. The changes in the concentrations of acute-phase proteins are due largely to changes in their production by hepatocytes induced by pro-inflammatory cytokines. Because of its specificity, sensibility and short half-life, C-reactive protein is the most useful indicator among all the acute-phase proteins. The clinical strategy to deal with an acute-phase response is to search the aetiology: infections, neoplasms, auto-immune and allergic diseases. The treatment of an acute-phase response is the treatment of its aetiology.
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