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Gnetol as a potent tyrosinase inhibitor from genus Gnetum
Kenji Ohguchi1, Toshiyuki Tanaka, Ibrahim Iliya
1Gifu International Institute of Biotechnology, Mitake, Kani-gun, Gifu 505-0116, Japan. kohguchi@giib.or.jp
Bioscience, Biotechnology, and Biochemistry
|May 2, 2003
Abstract:
Gnetol (2,3',5',6-tetrahydroxy-trans-stilbene), a naturally occurring compound particularly found in the genus Gnetum, had a strong inhibitory effect on murine tyrosinase activity. Gnetol (IC50, 4.5 microM) was stronger than kojic acid (IC50, 139 microM) as a standard inhibitor for murine tyrosinase activity. Moreover, gnetol significantly suppressed, melanin biosynthesis in murine B16 melanoma cells.