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Fluoride varnish concentration gradient and its effect on enamel demineralization
Chad O Hazelrigg1, Jeffrey A Dean, Margherita Fontana
1Riley Hospital for Children, Indianapolis, Ind, USA. cohazelr@iupui.edu
Pediatric Dentistry
|May 2, 2003
Summary
Fluoride varnish effectively remineralizes tooth lesions, regardless of storage position in the tube. However, Duraflor shows a fluoride concentration gradient, while quantitative light fluorescence (QLF) can detect lesion changes.
Area of Science:
- Dental materials science
- Caries prevention research
- Biomaterials analysis
Background:
- Fluoride varnishes are crucial for caries prevention.
- Concerns exist regarding content separation in 10-mL fluoride varnish tubes.
- Understanding fluoride concentration distribution is vital for effective treatment.
Purpose of the Study:
- To measure fluoride concentration gradients in 10-mL fluoride varnish tubes based on storage.
- To compare fluoride gradients across Duraphat, Duraflor, and CavityShield.
- To assess the impact of these gradients on caries inhibition and detectability using quantitative light fluorescence (QLF).
Main Methods:
- Human teeth underwent a caries challenge and were treated with fluoride varnish samples.
- Varnishes included Duraphat and Duraflor stored horizontally and vertically, plus CavityShield unidose.
- Specimens were analyzed using quantitative light fluorescence (QLF) and confocal microscopy.
Main Results:
- No significant differences in fluoride concentration (ppm) were found between storage groups (P=.29).
- The dispensing order significantly affected fluoride concentration in Duraflor (P<.05) but not Duraphat (P=.99).
- QLF analysis revealed no significant differences in remineralization across varnishes or storage positions (P>.05).
Conclusions:
- All tested fluoride varnishes effectively remineralize incipient in vitro carious lesions.
- A fluoride concentration gradient was confirmed in Duraflor tubes.
- Quantitative light fluorescence (QLF) is effective in detecting demineralized and remineralized incipient lesions.