Related Experiment Video
Updated: Sep 8, 2026

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
Published on: June 18, 2013
Free amino-acid concentrations in the equine placenta: relationship to maternal and fetal plasma concentrations
Maureen Young1, W R Allen, N E P Deutz
1The Babraham Institute, Babraham, Cambridge CB2 4AT, UK. mauryoung@aol.com
Abstract:
Free amino-acid concentrations were measured in maternal venous and fetal umbilical vein plasma, and in the allantochorion, of Thoroughbred mares at term. Concentrations in maternal and fetal plasma were similar to those reported previously in equids. The concentrations of free amino-acids in the allantochorion were higher than those in the maternal and fetal plasmas and were characterised by high levels of the nonessential amino-acids as observed in other species. Fourteen of the 20 amino-acids measured had similar allantochorion/umbilical vein concentration ratios suggesting that simple gradient diffusion might play a part in their transfer from the placenta to the fetus.
Related Concept Videos
Drug Distribution: Plasma Protein Binding
Composition of Blood Plasma
Drug Concentrations: Measurements
Plasma —...
Factors Affecting Protein-Drug Binding: Protein-Related Factors
The physicochemical properties of a drug play a significant role in its ability to bind to proteins. Lipophilic drugs, which dissolve in fats, oils, and lipids, can be bound by...
Physiological Pharmacokinetic Models: Assumption with Protein Binding
Pharmacokinetics in Pediatric Patients: Drug Distribution

