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Effect of alpha-tocopherol on the oxidative modification of apolipoprotein E in human very-low-density lipoprotein
Hirofumi Arai1, Koji Uchida, Kenji Fukunaga
1Department of Biochemistry and Biomolecular Recognition, Yamaguchi University School of Medicine, Ube 755-8505, Japan.
Bioscience, Biotechnology, and Biochemistry
|May 6, 2003
Abstract:
The oxidative modification of apolipoprotein (apo) E and lipid peroxidation in human very-low-density lipoprotein (VLDL) induced by peroxynitrite and cupric ions in vitro were strongly suppressed by enrichment with alpha-tocopherol (alpha-Toc; 170 microM). Alpha-Toc also suppressed the decrease in the heparin-binding activity of apoE in the VLDL oxidation. These results suggest that alpha-Toc protected apoE in VLDL from oxidative stress.