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The design of 8,8-dimethyl[1,6]naphthyridines as potential anticonvulsant agents
Nigel E Austin1, Michael S Hadley, John D Harling
1Neurology & GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Research & Development Limited, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK.
Bioorganic & Medicinal Chemistry Letters
|May 6, 2003
Abstract:
Starting from a series of 7-linked tetrahydroisoquinoline derivatives, as exemplified by SB-270664, a new series of 8,8-dimethylnaphthyridine compounds has been identified. SAR studies around these attractive leads have provided compounds such as 12 which display excellent anticonvulsant activity and an encouraging pharmacokinetic profile in vivo.