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Multidrug resistance reversal activity of key ningalin analogues
Danielle R Soenen1, Inkyu Hwang, Michael P Hedrick
1The Scripps Research Institute and the Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Bioorganic & Medicinal Chemistry Letters
|May 6, 2003
Abstract:
Key analogue derivatives of the ningalins, potent multidrug resistance (MDR) reversal compounds, were examined resulting in the discovery of a potent MDR reversal agent that hypersensitizes P-gp resistant tumor cell lines to front-line conventional therapeutic agents.