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A new sterol sulfate, Sch 572423, from a marine sponge, Topsentia sp
Shu-Wei Yang1, Alexei Buivich, Tze-Ming Chan
1Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. shu-wei.yang@spcorp.com
Bioorganic & Medicinal Chemistry Letters
|May 6, 2003
Abstract:
Bioassay-guided fractionation of an active fraction from a marine sponge Topsentia sp. in our marine fraction library (MFL) led to the isolation and identification of halistanol sulfate (1) and a new sterol sulfate Sch 572423 (2). Compounds 1 and 2 were identified as P2Y(12) inhibitors with IC(50) of 0.48 and 2.2 microM, respectively. The general method of purification for the MFL library and the structure elucidation of compound 2 are described.