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Substituted bridged phenyl piperidines: orally active growth hormone secretagogues
Zhijian Lu1, James R Tata, Kang Cheng
1Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA. zhijian_lu@merck.com
Bioorganic & Medicinal Chemistry Letters
|May 6, 2003
Abstract:
A new series of growth hormone secretagogues have been discovered. The best compound, 26j, shows excellent ability to release growth hormone both in vitro and in vivo. The synthesis and biological activity of these compounds are discussed.