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[Pseudomyxoma peritonei (gelatinous peritonitis )].

N Angelescu1, A Bordea, E Popa

  • 1Laboratorul de Anatomie Patologică-Spitalul Colţea.

Chirurgia (Bucharest, Romania : 1990)
|May 7, 2003
PubMed
Summary

Pseudomyxoma peritonei (P.P.) is a rare condition involving mucinous material in the abdomen. Treatment combining surgery and chemotherapy offers a 60% 5-year survival rate, with better outcomes for benign cases.

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Area of Science:

  • Oncology
  • Gastroenterology
  • Surgical Pathology

Background:

  • Pseudomyxoma peritonei (P.P.) is a rare clinical entity characterized by mucinous ascites, neoplastic cells, and peritoneal implants.
  • The appendix is the most common origin (70-80%), followed by the ovary.
  • P.P. is classified into disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis.

Observation:

  • A retrospective analysis of 6 patients (2 female, 4 male) diagnosed with P.P. between 1984 and 2000.
  • Clinical and biological findings were non-specific, hindering preoperative diagnosis.
  • Lesions originated from appendiceal cystadenoma (benign/malignant), ovarian tumors, or other mucinous neoplasms.

Findings:

  • Surgical procedures varied based on disease character (4 benign, 2 malignant) and origin.

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  • Intraperitoneal chemotherapy (Thio-Tepa) was administered in 5 cases; systemic chemotherapy (5-FU, mitomycin) in one.
  • Operative morbidity and mortality were zero, with an average follow-up of 4.2 years.

    • Implications:

    • The global 5-year survival rate was 60% (100% for benign, 0% for malignant forms).
    • Treatment involves radical surgery and intraperitoneal chemohyperthermia in specialized centers.
    • Despite treatment advances, the prognosis for P.P. remains guarded, with a 50-70% 5-year survival rate.