[Merkel cell carcinoma]

Merkel Cell Carcinoma (MCC) is a rare and aggressive neuroendocrine dermal neoplasm. This study is a retrospective outcomes analysis of two cases of MCC with data regarding clinical, histopathological, immunohistochemistry and also surgical, chimio and radiological treatment. MCC is a rare dermal tumors, this tumors are most predictable found on sunexposed sites. Diagnosis is best accomplished by a thorough clinical evaluation coupled with light microscopy and defined panel of immunohistochemical studies which are necessary for the definitive diagnosis of Merkel cell carcinoma (cytokeratins, neuron specific enoiase and chromogranin). A lot of other disease must be included in the differential diagnosis. MCC is an aggressive tumor with local or locoregionale extension and distant spread by hematogen or lymphatic way. Surgical excision of tumor and regional lymphadenectomy is the first step of treatment completed with radiotherapy and chemotherapy bat in advanced studies the rate of local or distant recidives is high.