Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Preliminary study on reducing oral moist snuff use.

Dorothy K Hatsukami1, Amanda Edmonds, Susan Schulte

  • 1University of Minnesota, Tobacco Use Research Center, 2701 University Ave SE, #210, Minneapolis 55414, USA. hatsu001@umn.edu

Drug and Alcohol Dependence
|May 7, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of relighting cigarettes on biomarkers of carcinogen and toxicant exposures.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco·2026
Same author

Effects of unventilated versus ventilated filtered cigarettes on smoking behaviour and biomarkers of smoke exposure in a randomised clinical trial.

Tobacco control·2026
Same author

Cigarette relighting disparities and potential implications: Survey findings from a large US probability sample.

Addictive behaviors·2026
Same author

The impact of very low nicotine cigarettes on cannabis and alcohol use during a 12-week clinical trial.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco·2026
Same author

Changes in the Oral Microbiota after Switching from Smoking to Exclusive e-Cigarette Use in an 8-Week Product-Switching Trial.

Cancer prevention research (Philadelphia, Pa.)·2026
Same author

Titration of nicotine intake in smokers switching to reduced nicotine content cigarettes with access to alternative nicotine systems: Secondary analysis of a randomized clinical trial.

Addiction (Abingdon, England)·2026
Same journal

Opioid use disorder and hospital readmission in the United States from 2010 to 2022: Primary reasons and the complex interplay of comorbid conditions.

Drug and alcohol dependence·2026
Same journal

Impact of medicaid waivers on medication for opioid use disorders in residential facilities: Evidence from twenty-five states.

Drug and alcohol dependence·2026
Same journal

Mental and somatic multimorbidity among individuals with alcohol use disorder: A sex-stratified registry study.

Drug and alcohol dependence·2026
Same journal

Monitoring novel psychoactive substance trends on social media: Analysis of discussions and dashboard implementation.

Drug and alcohol dependence·2026
Same journal

A meta-analysis on the relationship between cultural identity and substance use among indigenous youth.

Drug and alcohol dependence·2026
Same journal

Examining heterogeneity in pathways between alcohol-related factors and drinking during topiramate pharmacotherapy: A person-specific analysis.

Drug and alcohol dependence·2026
See all related articles

Reducing oral moist snuff tobacco (ST) use may be a viable strategy for users unwilling to quit. This pilot study found that reducing ST use led to lower nicotine and nitrosamine exposure in male users.

Area of Science:

  • Tobacco cessation research
  • Oral health and carcinogen exposure

Background:

  • Tobacco reduction strategies are an alternative for users unable or unwilling to quit.
  • Limited data exists on the feasibility of reducing oral moist snuff tobacco (ST) use.
  • This pilot study investigated ST use reduction and its impact on carcinogen exposure.

Purpose of the Study:

  • To assess the feasibility of reducing oral moist snuff tobacco (ST) use.
  • To determine if ST use reduction leads to lower exposure to carcinogens.
  • To evaluate different intervention methods for ST use reduction.

Main Methods:

  • 40 male moist snuff users were randomized into four groups: nicotine gum, non-tobacco snuff, brand switching, or situational elimination.
  • Interventions aimed to reduce ST use or nicotine exposure by 25% for 2 weeks, then 50% for 6 weeks.

Related Experiment Videos

  • Follow-up assessments were conducted at 12 and 26 weeks.

    • Main Results:

    • Significant reductions in ST consumption (tins/week) and cotinine levels were observed across all groups.
    • An intent-to-treat analysis showed a 15% abstinence rate at 26 weeks.
    • Reduced nicotine exposure correlated with decreased nitrosamine exposure.

    Conclusions:

    • Reducing oral moist snuff tobacco (ST) use appears to be a feasible approach for users not planning immediate cessation.
    • Further research is warranted to explore the long-term efficacy and broader applicability of ST reduction strategies.