Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[To burn or to store].

D Ricquier1

  • 1CNRS-UPR 9078, Institut de Recherche Necker-Enfants Malades 9, rue Jules-Hetzel-92190 Meudon. ricquier@infobiogen.fr

Annales D'Endocrinologie
|May 8, 2003
PubMed
Summary
This summary is machine-generated.

This study investigates uncoupling proteins (UCPs) in brown adipose tissue, crucial for regulating body weight and energy expenditure through heat production. Understanding UCPs offers potential new strategies for treating metabolic disorders like obesity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Kinetic analyses guide the therapeutic decision in a novel form of moderate aromatic Acid decarboxylase deficiency.

JIMD reports·2013
Same author

The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes.

Journal of lipid research·2012
Same author

Biology of brown adipose tissue: view from the chair.

International journal of obesity (2005)·2010
Same author

Long-term follow-up of bezafibrate treatment in patients with the myopathic form of carnitine palmitoyltransferase 2 deficiency.

Clinical pharmacology and therapeutics·2010
Same author

Gestational age-related reference values for amniotic fluid organic acids.

Prenatal diagnosis·2009
Same author

Mitochondrial uncoupling proteins.

Current opinion in drug discovery & development·2009
Same journal

[18F]F-DOPA and [18F]F-FDG PET/CT for staging advanced medullary thyroid cancer.

Annales d'endocrinologie·2026
Same journal

Corrigendum to 'Pink adipose tissue: A paradigm of adipose tissue plasticity' [Ann. Endocrinol. 85 (2004) 248-51].

Annales d'endocrinologie·2026
Same journal

Intraoperative location of parathyroid glands during total thyroidectomy: a systematic review of the literature according to the PRISMA method.

Annales d'endocrinologie·2026
Same journal

Clinical and genetic diagnosis of PHP1A associated with hypogonadism in a young male: A case report.

Annales d'endocrinologie·2026
Same journal

Autoimmune features in acquired generalized lipodystrophy and anti-perilipin 1 antibodies: A case report.

Annales d'endocrinologie·2026
Same journal

The diagnostic challenge of occult glucocorticoid exposure causing Cushing's syndrome.

Annales d'endocrinologie·2026
See all related articles

Area of Science:

  • Biochemistry
  • Cell Biology
  • Physiology

Background:

  • Body weight regulation in mammals depends on balancing energy intake and expenditure, with thermogenesis playing a key role.
  • Individual differences in food efficiency and fat storage mechanisms contribute to metabolic variations.
  • Brown adipose tissue (BAT) is a thermogenic organ that oxidizes fatty acids to produce heat, activated by cold, birth, and arousal from hibernation.

Purpose of the Study:

  • To characterize the mitochondrial protein uncoupling protein (UCP) responsible for heat production in brown adipocytes.
  • To explore the role of UCPs in cellular thermogenesis and their potential implications for metabolic disorders.
  • To identify and understand the function of UCP homologs, such as UCP2, in various tissues.

Main Methods:

Related Experiment Videos

  • Characterization of the uncoupling protein (UCP) in brown adipose tissue mitochondria.
  • Molecular cloning of UCP and development of antibodies for cellular studies.
  • Identification of UCP homologs (e.g., UCP2) in different tissues and organisms.

Main Results:

  • Identified UCP as a key protein in brown adipocytes that uncouples respiration from ATP synthesis, leading to significant heat production.
  • Demonstrated the presence of brown adipocytes and UCP in various physiological states and conditions.
  • Discovered UCP2, a UCP homolog found in most human and animal tissues, suggesting broader roles beyond thermogenesis.

Conclusions:

  • UCPs are critical for thermogenesis in brown adipose tissue, impacting energy expenditure and body weight regulation.
  • The broader family of UCPs may have ancient roles in oxygen adaptation and free radical control, in addition to thermogenic functions.
  • Further research into UCPs and respiration uncoupling mechanisms could lead to novel therapeutic strategies for metabolic diseases, particularly obesity.