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Related Experiment Videos

Host-pathogen interactions during apoptosis.

Seyed E Hasnain1, Rasheeda Begum, K V A Ramaiah

  • 1Laboratory of Molecular and Cellular Biology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad 500 076, India. director@www.cdfd.org.in

Journal of Biosciences
|May 8, 2003
PubMed
Summary
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Pathogens manipulate host cell apoptosis to survive and infect. This review explores how viruses alter host cell death pathways, impacting infection outcomes and host defense mechanisms.

Area of Science:

  • * Molecular Biology
  • * Immunology
  • * Virology

Background:

  • * Host-pathogen interactions involve diverse responses like phagocytosis, cytokine release, and reactive oxygen species (ROS) production.
  • * Pathogens frequently interfere with host cell apoptosis (programmed cell death) to ensure their survival and facilitate invasion.
  • * Host cell apoptosis can also serve as a protective mechanism against pathogen infection.

Purpose of the Study:

  • * To review the intricate mechanisms by which viruses modulate host cell apoptosis.
  • * To highlight the significance of these viral strategies in the context of host-pathogen dynamics.
  • * To discuss the role of host protein translation machinery in virus-mediated apoptosis regulation.

Main Methods:

  • * This is a review article, synthesizing existing research.

Related Experiment Videos

  • * Analysis of scientific literature on virus-host interactions and apoptosis pathways.
  • * Discussion of molecular mechanisms underlying viral manipulation of host cell death.

    • Main Results:

    • * Pathogens actively control host apoptosis pathways, often abrogating it for successful invasion.
    • * Viral manipulation of host protein translation machinery is a key strategy to inhibit apoptosis.
    • * Both pathogen survival and host protection can be influenced by the induction or inhibition of apoptosis.

    Conclusions:

    • * Virus-mediated modulation of host cell apoptosis is a critical factor in determining infection outcome.
    • * Understanding these pathways is crucial for developing antiviral strategies and therapies.
    • * The interplay between viral proteins and host cell machinery offers targets for therapeutic intervention.