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Association of HLA-B12 with multiple sclerosis in India
N H Wadia1, V S Trikannad, P R Krishnaswamy
1Laboratory of Immunology in the Dept. of Pathology, Jaslok Hospital and Research Centre, Bombay, India.
Abstract:
In Indian patients with Multiple Sclerosis it was observed, upon testing for serum determinable histocompatibility antigens, that HLA-B12 antigen was present in excess (77.7%), in comparison with normal controls (13.8%). In fact, in the sub-group of 'clinically definite' patients, the B12 antigen excess was remarkable (84%). These preliminary findings seem to point to a different immunogenetic profile of Indian MS patients in comparison with Western and Japanese series. Relevant published information relating to the HLA-B12 alleles in disease processes is discussed in order to provide a basis for further work.