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Updated: Sep 26, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Unprecedented palladium-catalyzed cross-coupling reaction of alpha-bromo sulfoxides with boronic acids
Nuria Rodríguez1, Ana Cuenca, Carmen Ramírez de Arellano
1Departamento de Química Orgánica, Universidad de Valencia, Avda Vicent Andres Estelles s/n 46100 Burjassot-Spain.
Abstract:
[reaction: see text] A new Suzuki-type palladium-catalyzed reaction of boronic acids with alpha-bromo sulfoxides has been developed using a protocol similar to the well-documented reaction of boronic acids with aryl halides. Both cross-coupling and homocoupling processes were observed. The best yields in cross-coupling products were obtained when the presence of oxygen was carefully excluded using degassed solvents. The oxidative addition palladium complex intermediate could be isolated and characterized by X-ray single-crystal diffraction.
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