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New silyl ether reagents for the absolute stereochemical determination of secondary alcohols
R Thomas Williamson1, Ana C Barrios Sosa, Abhijit Mitra
1Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA. williar@wyeth.com
Organic Letters
|May 9, 2003
Abstract:
[reaction: see text] Herein we report a new set of silyl ether reagents for determining the enantiomeric purity and absolute stereochemistry of secondary alcohols. These derivatives are easily synthesized, provide straightforward spectroscopic results, and allow for facile recovery of the original chiral alcohol.