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Related Experiment Videos

N-nitroso compounds: detection in ambient air.

D H Fine, D P Rounbehler, N M Belcher

    Science (New York, N.Y.)
    |June 25, 1976
    PubMed
    Summary
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    Dimethylnitrosamine, a type of N-nitroso compound, was detected in air samples from Baltimore and Belle. This finding utilized a new, highly sensitive detection technique for N-nitroso compounds.

    Area of Science:

    • Environmental Chemistry
    • Analytical Chemistry
    • Toxicology

    Background:

    • N-nitroso compounds are a class of chemicals with known carcinogenic potential.
    • Previous analytical methods for detecting N-nitroso compounds lacked sufficient sensitivity.
    • Dimethylnitrosamine is a specific N-nitroso compound of environmental and health concern.

    Purpose of the Study:

    • To develop and apply a novel, highly selective detection technique for N-nitroso compounds.
    • To quantify the presence and concentration of dimethylnitrosamine in ambient air samples.
    • To investigate the occurrence of other unidentified N-nitroso compounds in the studied locations.

    Main Methods:

    • A new detection technique based on catalytic cleavage of the N-NO bond and nitrosyl radical detection was employed.

    Related Experiment Videos

  • The method achieved picogram-level sensitivity (1 part in 10^12).
  • Gas-liquid chromatography and high-performance liquid chromatography were used in conjunction with the new detector for confirmation.

    • Main Results:

    • Dimethylnitrosamine was detected in air samples from Baltimore (0.02–0.96 ppb) and Belle (0.014–0.051 ppb).
    • N-nitroso compounds were not detected in air samples from Philadelphia, Wilmington, or Waltham.
    • One to three unidentified N-nitroso compounds were also detected in Baltimore and Belle.

    Conclusions:

    • The new analytical method is highly effective for detecting trace levels of N-nitroso compounds in air.
    • Dimethylnitrosamine is present in the ambient air of industrial areas like Baltimore and Belle.
    • Further research is needed to identify the unknown N-nitroso compounds and their sources.