Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Splanchnic free fatty acid kinetics.

Michael D Jensen1, Sylvain Cardin, Dale Edgerton

  • 1Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA. jensen.michael@mayo.edu

American Journal of Physiology. Endocrinology and Metabolism
|May 9, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Burned at Sea During the World's Largest Maritime Exercise: Implications for Large-Scale Combat Operations.

Journal of burn care & research : official publication of the American Burn Association·2026
Same author

Adipose Tissue Resistance to the Antilipolytic Effect of Insulin and Niacin in Humans With Obesity.

Diabetes·2026
Same author

Evaluation of Rhesus and Cynomolgus Macaque Whole Blood During Prolonged Cold Storage.

Shock (Augusta, Ga.)·2026
Same author

A Scoping Review on Military Airway Studies.

Military medicine·2026
Same author

Meal fatty acid metabolism is associated with long-term weight gain in females-a retrospective cohort study.

The American journal of clinical nutrition·2026
Same author

Hepatic steatosis in humans is associated with preserved glucagon action on amino acid metabolism.

The Journal of clinical investigation·2025

Splanchnic free fatty acid (FFA) release is a reliable indicator of visceral adipose tissue lipolysis. This study found a strong relationship between FFA release from visceral fat and splanchnic FFA release in dogs.

Area of Science:

  • Metabolism
  • Physiology
  • Endocrinology

Background:

  • Visceral adipose tissue (VAT) is metabolically active and releases free fatty acids (FFAs).
  • Understanding the relationship between VAT FFA release and splanchnic FFA release is crucial for metabolic research.

Purpose of the Study:

  • To assess the relationship between visceral adipose tissue (VAT) free fatty acid (FFA) release and splanchnic FFA release.
  • To evaluate a model predicting FFA delivery to the liver from visceral fat.

Main Methods:

  • Determined steady-state splanchnic bed palmitate kinetics in eight dogs using arterial, portal vein, and hepatic vein catheters.
  • Collected samples at 14 intervals to measure FFA kinetics.
  • Utilized hepatic vein data to test a predictive model for FFA origin.

Related Experiment Videos

Main Results:

  • The model predicted 15% of hepatic palmitate delivery from visceral lipolysis, while 11% was observed (P = 0.004).
  • A strong correlation (r(2) = 0.63) existed between predicted and observed hepatic palmitate delivery.
  • Model overestimation of visceral FFA release was more pronounced at lower palmitate concentrations, potentially due to differential FFA uptake or hepatic release.

Conclusions:

  • Splanchnic FFA release, measured via hepatic vein samples, is strongly related to visceral adipose tissue FFA release into the portal vein.
  • Splanchnic FFA release serves as a valuable indicator of visceral adipose tissue lipolysis.
  • Discrepancies in FFA modeling may involve arterial vs. portal vein uptake or hepatic bed release.