Pneumatosis coli, a benign form of necrotising enterocolitis
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Updated: Sep 26, 2026

A Neonatal Mouse Model of Necrotizing Enterocolitis and Lamina Propria Isolation for Immune Cell Profiling
Published on: September 19, 2025
J N Travadi1, S K Patole, K Gardiner
1Department of Neonatal Pediatrics, King Edward Memorial Hospital for Women, Bagot Road, Subiaco, WA 6008, Australia. javeednt@hotmail.com
Abstract:
Necrotising enterocolitis (NEC) is the most common acquired gastrointestinal emergency in neonates. Presence of pneumatosis intestinalis is taken as evidence of definite NEC. A distinctive but rare form of NEC called "pneumatosis coli" has been described, presenting with gross blood in stools and minimal or absent local and systemic signs. Radio-graph characteristically reveal isolated colonic pneumatosis without small bowel involvement. Pneumatosis coli has a more benign course compared with definite NEC. Total parenteral nutrition, antibiotics, an appropriate duration off feeds and close observation remain the corner stones of therapy assuring a benign course.
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