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Related Experiment Video

Updated: Jul 3, 2026

Multifocal Electroretinograms

Multifocal Electroretinograms

Published on: December 4, 2011

Central and peripheral vision loss associated with nefazodone usage.

Chi Luu¹, Patricia Kiely, David Crewther

¹School of Psychological Science, La Trobe University, Bundoora, VIC 3086, Australia.

Documenta Ophthalmologica. Advances in Ophthalmology

|May 10, 2003

Summary

Nefazodone, an antidepressant, may cause vision loss due to retinal neurotoxicity. Electrophysiological tests revealed severe macular damage, suggesting a primary retinal origin for the patient's persistent vision problems.

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Area of Science:

Ophthalmology
Neuroscience
Pharmacology

Background:

Antidepressant medications like nefazodone can have ocular side effects.
Persistent vision loss following nefazodone use warrants thorough electrophysiological investigation.

Observation:

A 35-year-old woman experienced progressive vision loss, including reduced acuity, color vision, and visual field constriction, three years after a brief course of nefazodone.
Electrophysiological assessments, including multifocal electroretinograms (mfERGs) and visual evoked potentials (VEPs), were performed to evaluate the visual pathway.

Findings:

While overall retinal responses were normal, mfERGs showed severe macular depression in both eyes.
Multifocal VEP mapping indicated central visual processing deficits, more pronounced in the right eye.
Abnormal responses to motion stimuli further suggested cortical processing issues.

Implications:

The findings strongly suggest retinal neurotoxicity as the primary cause of vision loss, rather than functional or hysterical causes.
This case highlights the potential for delayed and persistent visual impairment from nefazodone, emphasizing the need for careful patient monitoring.
Further research into the specific mechanisms of nefazodone-induced retinal toxicity is warranted.