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Synthesis of protein-nucleic acid conjugates by expressed protein ligation
Marina Lovrinovic1, Ralf Seidel, Ron Wacker
1Universität Dortmund, Fachbereich Chemie, Biologisch-Chemische Mikrostrukturtechnik, Otto-Hahn Str. 6, D-44227 Dortmund, Germany.
Chemical Communications (Cambridge, England)
|May 13, 2003
Abstract:
The synthesis of covalent conjugates of proteins and polyamide nucleic acids (PNA) is accomplished by expressed protein ligation of intein-fusion proteins and a PNA-cysteine conjugate.