Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A journey from neocortex to hippocampus.

T V P Bliss1

  • 1Division of Neurophysiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK. tbliss@nimr.mrc.ac.uk

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|May 13, 2003
PubMed
Summary

Researchers sought rules for neural plasticity in the brain. Initial neocortex studies failed, leading to a focus on the hippocampus for understanding memory encoding.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term potentiation: 50 years on: past, present and future.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2024
Same author

Synaptic plasticity in health and disease: introduction and overview.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2013
Same author

ARG3.1/ARC expression in hippocampal dentate gyrus astrocytes: ultrastructural evidence and co-localization with glial fibrillary acidic protein.

Journal of cellular and molecular medicine·2008
Same author

Plasticity in the human central nervous system.

Brain : a journal of neurology·2006
Same author

Sexual dimorphisms in the effect of low-level p25 expression on synaptic plasticity and memory.

The European journal of neuroscience·2005
Same author

Long-term potentiation in the rat dentate gyrus is associated with enhanced Arc/Arg3.1 protein expression in spines, dendrites and glia.

The European journal of neuroscience·2005

Area of Science:

  • Neuroscience
  • Cognitive Science

Background:

  • The engram, or neural trace of memory, was hypothesized to involve Hebbian learning in neurons.
  • Synaptic efficacy modification by neural activity was the proposed mechanism for memory encoding.

Observation:

  • Early research focused on identifying rules for cortical plasticity in the neocortex.
  • Attempts to uncover these rules in the neocortex were unsuccessful.

Findings:

  • The neocortex proved challenging for elucidating principles of neural plasticity.
  • The hippocampus emerged as a more promising brain region for studying memory encoding mechanisms.

Implications:

  • Understanding hippocampal plasticity is crucial for deciphering memory formation.
  • This research highlights the importance of brain region selection in neuroscience investigations.

Related Experiment Videos