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Updated: Aug 4, 2026

Whole-Body Nanoparticle Aerosol Inhalation Exposures
Published on: May 7, 2013
Phonatory threshold pressure in a healthy population before and after aerosol treatment, a preliminary study
M N Grini-Grandval1, S Bingenheimer, R Maunsell
1CHU de la Timone (Pr M Zanaret), Fédération d'ORL et CCF, Hopital d' Adulte de la Timone, 264, rue Saint-Pierre, F-13385 Marseille, France
Abstract:
The viscosity of the surface mucus of the vocal cords is one of the important elements for good laryngeal functioning. It has been demonstrated that inhalation of hydrated air increases the phonatory threshold pressure by decreasing viscosity of the mucus (1) leading to a more regular vibration that can be appreciated by jitter (2). In an attempt to correlate the concepts of tissue viscosity and surface mucus considering the theoretical model of vibration we measured the phonatory threshold pressure in 6 healthy female subjects before and after aerosol treatment. We were able to demonstrate that the pressure threshold is lower (3.15 hPa) after aerosol treatment than before (3.79 hPa) and this was statistically significant (p: 0.041). The discussion is based on this decrease of mucus viscosity applied to the physiological concepts necessary to understand glottic vibration.

