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Transmural action potential changes underlying ventricular electrical remodeling.

Imad Libbus1, David S Rosenbaum

  • 1The Heart and Vascular Research Center, Department of Medicine, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio 44109-1998, USA.

Journal of Cardiovascular Electrophysiology
|May 14, 2003
PubMed
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Ventricular electrical remodeling, or changes in heart cell repolarization, can be induced by rapid heart rates or altered activation sequences. These changes persist even after normal conditions are restored, impacting cardiac function.

Area of Science:

  • Cardiovascular Physiology
  • Cardiac Electrophysiology

Background:

  • Electrical remodeling in the atria is well-understood.
  • Ventricular electrical remodeling mechanisms remain unclear.

Purpose of the Study:

  • To investigate ventricular electrical remodeling caused by altered heart rate and activation sequence.
  • To determine changes in cellular repolarization during ventricular remodeling.

Main Methods:

  • Simultaneous optical action potential recording from 256 sites in canine ventricular wedge preparations.
  • Comparison of action potentials before and after periods of rapid pacing or altered activation sequence.
  • Analysis of action potential duration (APD) and APD gradient orientation.

Main Results:

Related Experiment Videos

  • Rapid heart rate shortened action potential duration (APD) by 24.8 msec.
  • Altered activation sequence prolonged APD by 12.7 msec.
  • Significant changes in APD gradient orientation occurred after both interventions.

Conclusions:

  • Short periods of altered heart rate or activation sequence induce persistent ventricular electrical remodeling.
  • Ventricular remodeling differs from atrial remodeling.
  • Altered activation sequence can prolong APD, while rapid rates can alter repolarization gradient orientation.