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Updated: Sep 26, 2026

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
Published on: November 7, 2020
Ten years of sirolimus therapy in orthotopic liver transplant recipients
G W Neff1, M Montalbano, A G Tzakis
1University of Miami, Miami, Florida, USA.
Background:
Sirolimus therapy has been used in orthotopic liver transplant (OLT) recipients diagnosed with a variety of diseases; chronic graft rejection (CR), calcineurin associated renal toxicity, preemptive immune suppression, calcineurin related neurotoxicity, preemptive therapy in transplant recipients with history of hepatocellular carcinoma, and steroid resistant allograft rejection.
Methods:
A search for the medical literature and experiences involving sirolimus was done.
Results:
Several animal and human reports evaluating the use sirolimus in liver transplant recipients are found and discussed.
Conclusion:
Sirolimus has been used for multitude of indications, primarily based on anecdotal experiences. However, reports of sirolimus related side effects have decreased the transplant communities' enthusiasm towards promoting this agent as a safe immune suppression agent.
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