Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Fatigue damage and repair in bone].

Chunqiu Zhang1, Dankai Wu, Yuxiang Guo

  • 1Department of Mechanics, College of Mechanical Science and Engineering, Jilin University, Changchun 130022.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi
|May 15, 2003
PubMed
Summary

Bone experiences fatigue damage from everyday loads, leading to microcracks. The body repairs this microdamage through bone remodeling, a process involving osteocytes and mathematical models for clinical application.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physical exercise and social adaptation among Left-Behind and non-Left-Behind Children in China: The mediating role of perceived physical health.

Acta psychologica·2026
Same author

The signaling mechanism of phyA involves direct interaction with ATG8 to regulate HY5 autophagic degradation under nutrient starvation.

The New phytologist·2026
Same author

Observation of Five Distinct Localization Phases in a 1D Floquet System.

Physical review letters·2026
Same author

Unified characterization of the complete hierarchy of topological boundary states in a Floquet crystal.

National science review·2026
Same author

RNase III-deficient Bacillus thuringiensis enables stable dsRNA production and enhances HD1 activity against Spodoptera frugiperda.

Pest management science·2026
Same author

Thermosensitive Injectable Hydrogel Incorporating Telopeptide-Free Type I Collagen Promotes Cartilage Regeneration: An In Vivo Study.

Tissue engineering and regenerative medicine·2026

Area of Science:

  • Biomechanics
  • Materials Science
  • Cell Biology

Context:

  • Bone is a load-bearing organ susceptible to fatigue damage from physiological loads.
  • Microcracks, even at the hydroxyapatite crystal level, can form during habitual use or vigorous activity.
  • Bone possesses an intrinsic repair capacity through a process called bone remodeling.

Purpose:

  • To investigate the mechanisms of fatigue damage in bone.
  • To understand the role of osteocytes in signaling during bone repair.
  • To develop mathematical and mechanical models for bone fatigue and repair.

Summary:

  • Fatigue damage in bone involves the formation of microcracks, often at a microscopic level.
  • Bone remodeling, orchestrated by osteocytes, is the primary mechanism for repairing such microdamage.

Related Experiment Videos

  • Mathematical and mechanical models are being developed to better comprehend and clinically apply bone fatigue and repair processes.

    • Impact:

    • Improved understanding of bone's response to mechanical stress.
    • Potential for enhanced clinical strategies in treating bone injuries and diseases.
    • Advancement in the development of predictive models for bone health and fracture risk assessment.