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Updated: Sep 26, 2026

A Unified Methodological Framework for Vestibular Schwannoma Research
Published on: June 20, 2017
A general framework for neurobiological modeling: an application to the vestibular system
Chris Eliasmith1, M B Westover, C H Anderson
1Department of Philosophy, Department of Systems Design Engineering, University of Waterloo, Waterloo, Ont., Canada.
Abstract:
The otolith organs in the vestibular system are excellent detectors of linear accelerations. However, any measurement of linear acceleration is ambiguous between a tilt in a gravitational field and an inertial acceleration. Angelaki et al. have put forward a general hypothesis about how inertial accelerations can be computed based on vestibular signals (J. Neurosci. 19 (1999) 316). We have constructed a realistic, detailed model of the relevant systems to test this hypothesis. The model produces useful predictions about what kinds of neurons should be found in the vestibular nucleus if such a computation is actually performed in the vestibular system. The model is constructed using general principles of neurobiological simulation (J. Neurophys. 84 (2000) 2113).
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