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Neurotrophins in myelination: a new role for a puzzling receptor
1Department of Neuroscience, College of Medicine, McKnight Brain Institute of the University of Florida, Box 100244, Gainesville, FL 32610, USA. notterp@ufbi.ufl.edu
Trends in Neurosciences
|May 15, 2003
Abstract:
Binding of neurotrophins to p75(NTR) was recently identified as a positive signal for myelination by Schwann cells. This new finding adds yet another distinct biological role to the growing list of functions of p75(NTR) in the nervous system and identifies a novel target for promoting remyelination in peripheral neuropathies or post-nerve-injury.