Related Experiment Video
Updated: Sep 7, 2026

Modeling the Functional Network for Spatial Navigation in the Human Brain
Published on: October 13, 2023
Spatial navigation and the basal forebrain in Alzheimer's disease and other neurodegenerative diseases
Martina Laczó1, Ondrej Lerch1, Zuzana Nedelska1
1Department of Neurology, Second Faculty of Medicine, Charles University, Motol and Homolka University Hospital, Prague, Czechia.
Abstract:
Neurodegenerative diseases such as Alzheimer's disease (AD) and Lewy body disease (LBD) are frequently associated with spatial navigation impairments. However, these impairments are less pronounced in frontotemporal dementia and limbic-predominant age-related TDP-43 encephalopathy. While basal forebrain degeneration occurs in all of these diseases, disruption of cholinergic pathways and related cholinergic deficits has been primarily observed in AD and LBD, and in both of these conditions, basal forebrain degeneration appears to be associated with spatial navigation deficits. In this review, we discuss current understanding of spatial navigation impairments in neurodegenerative diseases, with a particular focus on disease-related changes in the basal forebrain and their associations with impaired spatial navigation abilities in humans.
More Related Videos
Related Concept Videos
Alzheimer Disease ll: Pathophysiology
Dementia l: Introduction
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease l: Introduction
Role of Hippocampus in Memory

