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Prolonged systemic delivery of tirofiban in a thrombus-laden saphenous vein graft

Luis Gruberg1, Shlomo Amikam

  • 1Division of Invasive Cardiology, Rambam Medical Center, The Technion-Israel Institute of Technology, Haifa, Israel. gruberg67@hotmail.com

International Journal of Cardiovascular Interventions
|May 15, 2003
PubMed

Insights

Systemic tirofiban effectively resolved a large thrombus in a degenerated saphenous vein graft, restoring normal coronary blood flow. This finding suggests potential for glycoprotein IIb/IIIa inhibitors in managing acute coronary syndromes.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Pharmacology

Background:

  • Conflicting results exist regarding local thrombolytic delivery for reducing thrombus burden in coronary interventions.
  • Degenerated saphenous vein grafts are prone to thrombus formation, complicating acute coronary syndromes.

Observation:

  • A patient presented with acute coronary syndrome due to a large thrombus (TIMI grade 4) in a degenerated saphenous vein graft.
  • The patient received 24 hours of systemic tirofiban (a glycoprotein IIb/IIIa inhibitor).

Findings:

  • Complete resolution of the saphenous vein graft thrombus was observed.
  • Normal coronary blood flow was restored 48 hours post-treatment.

Implications:

  • Systemic tirofiban may be a viable therapeutic option for managing large thrombi in degenerated saphenous vein grafts.
  • This case highlights the efficacy of glycoprotein IIb/IIIa inhibitors in achieving thrombus resolution in complex coronary interventions.

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