Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Single nucleotide polymorphism genotyping: biochemistry, protocol, cost and throughput.

X Chen1, P F Sullivan

  • 1Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298-0424, USA. xchen@vcu.edu

The Pharmacogenomics Journal
|May 15, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

NDVI changes in the Arctic: Functional significance in the moist acidic tundra of Northern Alaska.

PloS one·2023
Same author

Dysregulation of Synaptic and Developmental Transcriptomic/Proteomic Profiles upon Depletion of MUNC18-1.

eNeuro·2022
Same author

Technological readiness and implementation of genomic-driven precision medicine for complex diseases.

Journal of internal medicine·2021
Same author

Stitching the synapse: Cross-linking mass spectrometry into resolving synaptic protein interactions.

Science advances·2020
Same author

Unraveling the genetic architecture of major depressive disorder: merits and pitfalls of the approaches used in genome-wide association studies.

Psychological medicine·2019
Same author

Correction: Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa.

Molecular psychiatry·2018

Single nucleotide polymorphism (SNP) genotyping technologies are crucial for disease association studies. This review details current SNP typing methods, comparing their features, costs, and applications for researchers.

Area of Science:

  • Genetics
  • Genomics
  • Biotechnology

Background:

  • Large numbers of single nucleotide polymorphism (SNP) markers are publicly available, enabling practical association studies and fine mapping of disease loci.
  • Researchers often need to utilize SNP genotyping technologies but may not be experts in the field.

Purpose of the Study:

  • To review recent developments in single nucleotide polymorphism (SNP) genotyping technologies.
  • To provide researchers with essential information on SNP typing protocols and methods.

Main Methods:

  • General description of SNP typing protocols.
  • Summary of current methods for each step of SNP typing.
  • Comparison of technique features, weaknesses, cost, and throughput.
  • Description of popular techniques and their suitable applications.

Related Experiment Videos

Main Results:

  • Detailed overview of various SNP genotyping protocols and their methodologies.
  • Comparative analysis highlighting unique features, limitations, and cost-effectiveness of different techniques.
  • Identification of suitable applications for popular SNP genotyping methods.

Conclusions:

  • SNP genotyping technologies are essential tools for genetic research, particularly in disease association and fine mapping.
  • Understanding the diverse available methods, their strengths, and weaknesses is crucial for selecting the most appropriate technology for specific research needs.