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Updated: Jan 14, 2026
Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
Published on: September 16, 2021
Preventing ovarian hyperstimulation syndrome by inhibiting the effects of vascular endothelial growth factor
Bernie McElhinney1, Joy Ardill, Carolyn Caldwell
1Department of Obstetrics and Gynaecology, School of Medicine, Queen's University Belfast, Institute of Clinical Science, Grosvenor Road, Belfast, Northern Ireland, BT12 6BJ. b.mcelhinney@qub.ac.uk
Objective:
To evaluate whether inhibiting the effects of vascular endothelial growth factor can prevent the ovarian hyperstimulation syndrome.
Study Design:
Rates were hyperstimulated with follicle-stimulating hormone injections. On the final day of stimulation, the rats were randomized to receive or not receive exogenous soluble fmslike tyrosine kinase (sFlt-1). Forty-eight hours later capillary permeability was determined by measuring the concentration of Evans blue dye (EB) in peritoneal irrigation fluid 3 minutes after an intravenous injection of EB.
Results:
The peritoneal EB level was statistically significantly lower in the hyperstimulated group, which received the sFlt-1, than in the stimulation-only group.
Conclusion:
sFlt-1 may play a therapeutic role in management of the ovarian hyperstimulation syndrome by specifically inhibiting the effects of vascular endothelial growth factor.
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