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Central corneal abscess.

O P van Bijsterveld

    American Journal of Ophthalmology
    |May 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Staphylococcal inoculation caused central corneal abscesses in rabbits, particularly with high doses and in immunized animals. These abscesses did not lead to ulceration, showing polymorphonuclear leukocytes within the corneal lamellae.

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    Area of Science:

    • Ophthalmology
    • Microbiology
    • Immunology

    Background:

    • Staphylococcal infections can cause ocular pathologies.
    • Corneal lesions are susceptible to bacterial invasion.
    • Immune status may influence infection outcomes.

    Purpose of the Study:

    • To investigate the development of corneal abscesses following staphylococcal inoculation.
    • To determine factors influencing abscess formation and ulceration.
    • To characterize the histological features of induced corneal lesions.

    Main Methods:

    • Induction of paracentral epithelial lesions in rabbit corneas.
    • Inoculation with biologically active staphylococcal strains.
    • Histological examination of corneal tissues.

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    Main Results:

    • Central corneal abscesses formed after inoculation.
    • Abscess development required high bacterial inocula.
    • Abscesses were more frequent in immunized rabbits.
    • No ulceration occurred at the initial lesion site or elsewhere.
    • Histology revealed dense polymorphonuclear leukocytes within corneal lamellae.

    Conclusions:

    • Staphylococcal strains can induce central corneal abscesses without ulceration.
    • High inocula and prior immunization increase abscess frequency.
    • Polymorphonuclear leukocyte infiltration is a key feature of these lesions.