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Related Experiment Videos

Urinary calculus during methazolamide therapy.

M B Shields, R J Simmons

    American Journal of Ophthalmology
    |May 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Methazolamide, a glaucoma medication, may increase the risk of kidney stones. A patient developed calcium oxalate and calcium phosphate stones after starting this drug.

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    Area of Science:

    • Nephrology
    • Ophthalmology
    • Pharmacology

    Background:

    • Paget's disease and open-angle glaucoma are chronic conditions.
    • Methazolamide is a carbonic anhydrase inhibitor used to treat glaucoma.
    • Renal calculi (kidney stones) can be a complication of Paget's disease.

    Observation:

    • A 68-year-old male patient with Paget's disease and open-angle glaucoma was prescribed methazolamide.
    • The patient developed ureteral colic and a calcium oxalate stone 10 months after initiating methazolamide.
    • Following reinstitution of methazolamide, the patient passed three calcium phosphate stones.

    Findings:

    • A potential causal relationship between methazolamide use and the formation of both calcium oxalate and calcium phosphate stones was observed.

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  • The patient's history of Paget's disease and brief prior acetazolamide use were noted as potential confounding factors.

    • Implications:

    • This case suggests methazolamide may be associated with an increased risk of nephrolithiasis (kidney stone formation).
    • Further investigation is warranted to confirm the association between methazolamide and kidney stone development.
    • Clinicians should consider the potential risk of kidney stones in patients prescribed methazolamide, particularly those with predisposing factors.