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Bowel cleansing for diagnostic colonoscopy: which method is preferable? Istanbul experience
1Department of General Surgery, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey. ihsantasci@yahoo.com
Techniques in Coloproctology
|May 17, 2003
Summary
Two doses of oral sodium phosphate (NaP) plus domperidone offer superior colon cleansing for colonoscopy. This bowel preparation method is safe, effective, and well-tolerated by patients.
Area of Science:
- Gastroenterology
- Endoscopy
- Pharmacology
Background:
- A prospective randomized trial involving 953 patients evaluated bowel preparations for colonoscopy.
- Assessing cleansing efficacy and patient tolerance is crucial for optimizing colonoscopy procedures.
Purpose of the Study:
- To compare the colon cleansing ability and tolerance of various bowel preparation regimens.
- To identify the most effective and well-tolerated bowel preparation for colonoscopy.
Main Methods:
- Patients received different bowel preparations including sennoside calcium, polyethylene glycol (PEG) lavage, and oral sodium phosphate (NaP) in various single and double doses.
- Some NaP regimens were combined with cisapride or domperidone.
- The cisapride-containing regimen was discontinued due to adverse effects.
Main Results:
- Oral sodium phosphate (NaP) combined with domperidone demonstrated significantly better colon cleansing than other methods (p<0.05).
- NaP plus cisapride also showed superior cleansing but was abandoned due to adverse events.
- Sennoside calcium and PEG lavage were associated with significantly worse tolerance (p<0.05).
Conclusions:
- A two-dose regimen of oral sodium phosphate (NaP) solution (45 ml + 90 ml) combined with domperidone is a safe and effective bowel preparation for colonoscopy.
- This regimen is rapid, inexpensive, and well-tolerated, making it a favorable option for colon cleansing.