Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Blastomycosis.

Robert W Bradsher1, Stanley W Chapman, Peter G Pappas

  • 1University of Arkansas for Medical Sciences, Central Arkansas Veterans Administration, Little Rock, AR, USA. bradsherrobertw@uams.edu

Infectious Disease Clinics of North America
|May 20, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epidemiology and Clinical Features of Cryptococcosis Among Individuals Without HIV Infection: An Observational International Multicenter Study (MSG-11).

Open forum infectious diseases·2026
Same author

Exploring Early Antifungal Activity of Rezafungin as a Stepping-Stone for Shorter Treatment Duration for Candidemia: Pooled Analysis of 2 Randomized Trials.

Open forum infectious diseases·2026
Same author

Development Framework of Desirability of Outcome Ranking Endpoints for Use in Clinical Trials of Invasive Fungal Diseases.

Open forum infectious diseases·2026
Same author

Rezafungin Versus Caspofungin for the Treatment of Candidemia and Invasive Candidiasis: Results from the Double-blind, Randomized, Phase 3 ReSTORE Trial Including the China Extension Study.

Open forum infectious diseases·2025
Same author

Histopathologic Insights Into Curvularia-Induced Chronic Granulomatous Fungal Sinusitis: A Guide for Surgical Pathologists.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2025
Same author

COVID-19-associated Pulmonary Aspergillosis in Mechanically Ventilated Patients at 7 US Hospitals: Epidemiology and Estimated Likelihood of Invasive Pulmonary Aspergillosis-Results of the Prospective MSG-017 Study.

Open forum infectious diseases·2025
Same journal

Prevention and Control of Clostridioides difficile Infection for the Infectious Diseases Clinician.

Infectious disease clinics of North America·2026
Same journal

Infection Control Strategies to Prevent Emergence and Transmission of Resistant Gram-Negative Bacteria.

Infectious disease clinics of North America·2026
Same journal

Preventing the Spread of Tuberculosis in Health Care Settings.

Infectious disease clinics of North America·2026
Same journal

Threats to Success: Principles of Infection Prevention and Control in Health Care Settings, Part 2: Device and Pathogen Management.

Infectious disease clinics of North America·2026
Same journal

Ventilator-Associated Events: Surveillance and Prevention.

Infectious disease clinics of North America·2026
Same journal

Nosocomial Fungal Infections: Epidemiology, Control Strategies, and Prevention of Candida and Other Yeasts.

Infectious disease clinics of North America·2026
See all related articles

Blastomycosis, a fungal infection endemic to the central US, can cause mild or severe pulmonary and extrapulmonary disease. Itraconazole is the primary treatment, with amphotericin B reserved for life-threatening infections.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Epidemiology

Background:

  • Blastomycosis is an endemic mycosis in the central United States caused by the dimorphic fungus, Blastomyces dermatitidis.
  • Blastomyces dermatitidis exists in nature as a mycelial form and converts to a yeast form at body temperature.
  • Infections can manifest as epidemics from a single source or as sporadic endemic cases.

Purpose of the Study:

  • To describe the epidemiology and clinical presentation of blastomycosis.
  • To outline treatment strategies for blastomycosis, including drug of choice and alternatives.

Main Methods:

  • Review of endemic mycoses literature.
  • Clinical case analysis of Blastomycosis infections.
  • Pharmacological review of antifungal agents for Blastomycosis.

Related Experiment Videos

Main Results:

  • Blastomycosis can present as subclinical illness or progressive pulmonary and/or extrapulmonary disease.
  • Cellular immune mechanisms may confer protection against progressive infection.
  • Itraconazole is the recommended treatment for most cases.

Conclusions:

  • Blastomycosis is a significant endemic mycosis requiring prompt diagnosis and treatment.
  • Itraconazole is the preferred agent, while amphotericin B is crucial for severe, life-threatening infections.