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Clinical pharmacology of antifungal compounds
Andreas H Groll1, Juan C Gea-Banacloche, Axel Glasmacher
1Infectious Disease Research Program, Center for Bone Marrow Transplantation, Department of Pediatric Hematology/Oncology, Wilhelms-University Medical Center, Domagkstrasse 9a, 48149 Muenster, Germany. grollan@mednet.uni-muenster.de
Abstract:
Prompted by the worldwide surge in fungal infections, the past decade has witnessed a considerable expansion in antifungal drug research. New compounds have entered the clinical arena, and major progress has been made in defining paradigms of antifungal therapies. This article provides an up-to-date review on the clinical pharmacology, indications, and dosage recommendations of approved and currently investigational therapeutics for treatment of invasive fungal infections in adult and pediatric patients.