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The relationship between serum trace element changes and visual function in heavy smokers.

Efkan Uz1, Semsettin Sahin, Ibrahim F Hepsen

  • 1Department of Medical Biology and Genetics, Suleyman Demirel University, Faculty of Medicine, Isparta, Turkey.

Acta Ophthalmologica Scandinavica
|May 20, 2003
PubMed
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Heavy smokers show reduced contrast sensitivity and lower serum manganese and zinc levels, suggesting a link between these trace elements and early retinal toxicity from smoking.

Area of Science:

  • Ophthalmology
  • Toxicology
  • Nutritional Science

Background:

  • Smoking is a major public health concern with known systemic effects.
  • Ocular health can be impacted by various environmental and lifestyle factors.
  • Trace elements play crucial roles in cellular function and antioxidant defense.

Purpose of the Study:

  • To investigate serum manganese (Mn), zinc (Zn), and copper (Cu) levels in heavy smokers.
  • To evaluate visual functions, including contrast sensitivity, in heavy smokers compared to non-smokers.
  • To explore the relationship between trace element levels and visual function changes in smokers.

Main Methods:

  • Prospective study comparing 24 heavy smokers with 16 healthy non-smokers.
  • Serum Mn, Zn, and Cu levels measured using atomic absorption spectrophotometry.

Related Experiment Videos

  • Visual functions assessed included visual acuity, color vision, pattern visual evoked potentials (PVEPs), and contrast sensitivity.

    • Main Results:

    • Heavy smokers exhibited significantly reduced contrast sensitivity compared to non-smokers.
    • Mean serum Mn and Zn levels were significantly lower in heavy smokers.
    • Visual acuity, color vision, and PVEPs remained normal in both groups.

    Conclusions:

    • Lower serum Mn and Zn levels in smokers are associated with reduced contrast sensitivity.
    • These findings suggest a potential role for trace elements in smoking-induced early retinal toxicity.
    • Mn and Zn, as superoxide dismutase cofactors, may be involved in protecting against smoking-related oxidative stress in the retina.