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The herpesvirus-Porphyromonas gingivalis-periodontitis axis.
1University of Southern California, School of Dentistry, Los Angeles, CA 90089-0641, USA. jslots@usc.edu
Journal of Periodontal Research
|May 20, 2003
Summary
Human cytomegalovirus (HCMV) and herpes simplex virus (HSV) are linked to Porphyromonas gingivalis, a key factor in severe periodontitis. These viruses may trigger or contribute to periodontal disease progression.
Area of Science:
- Oral microbiology
- Periodontology
- Virology
Background:
- Herpesviruses are increasingly implicated in severe periodontitis.
- The interaction between specific herpesviruses and Porphyromonas gingivalis in periodontal disease pathogenesis requires further investigation.
Purpose of the Study:
- To investigate the potential interaction between human cytomegalovirus (HCMV), Epstein-Barr virus type 1 (EBV-1), and herpes simplex virus (HSV) with Porphyromonas gingivalis in the development of periodontal breakdown.
Main Methods:
- Paper point samples were collected from 16 subjects with progressing and stable periodontitis lesions.
- Polymerase chain reaction (PCR) was used to detect subgingival herpesviruses and bacteria.
- Statistical analyses included Chi-squared tests and logistic regression.
Main Results:
- HCMV and HSV were significant predictors of subgingival P. gingivalis presence.
- P. gingivalis correlated with active periodontitis, attachment loss, pocket depth, bleeding, and age.
- EBV-1 predicted active disease but was not linked to P. gingivalis.
Conclusions:
- HCMV, HSV, and P. gingivalis are implicated as cofactors or relapse triggers in aggressive periodontitis.
- Further research is needed to understand the role of herpesviruses in periodontopathogenicity and their management.